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Har Gobind Khorana
Facts
Har Gobind Khorana
Born on 9 Jan, 1922
Died on 9 Nov, 2011
Research areas
Major contribution
Wikipedia Article
Contents
1
Wikipedia Article
2
Lectures
3
Other resources
4
Publications
4.1
1958
4.2
1959
4.3
1963
4.4
1964
4.5
1965
4.6
1967
4.7
1968
4.8
1974
4.9
1979
4.10
1981
4.11
1984
4.12
1986
4.13
1995
4.14
1997
4.15
1998
4.16
1999
4.17
2001
4.18
2002
4.19
2003
4.20
2005
5
Videos
Article about Khorana
Lectures
Nobel lecture
Feodor Lynen lecture in 1981
Other resources
From Nobel prize website
Letter from Arthur Kornberg
(1956)
Letter to Arthur Kornberg
(1957)
Letter from Arthur Kornberg
(1957)
Letter from Arthur Kornberg
(Feb 28, 1957)
Khorana program lecture
Publications
List of publications by or about Khorana in Pubmed
1958
Pyrophosphorylation of ribose 5-phosphate in the enzymatic synthesis of 5-phosphorylribose 1-pyrophosphate
1959
The mode of action of ryegrass ribonuclease
1963
Preparation of nucleotides and derivatives
1964
Enzymatic Synthesis of Deoxyribonucleic Acid, XVI. Oligonucleotides as Templates and The Mechanism of Their Replication
Polynucleotides. XXVIII. Synthetic deoxyribopolynucleotides as templates for ribonucleic acid polymerase; theformation and characterization of a ribopolynucleotide with a repeating trinucleotide sequence
Enzymic synthesis of deoxyribonucleic acid (DNA). XVI. Oligonucleotides as templates and the mechanism of theirreplication
1965
Studies on Polynucleotides. XXXV. The Specific Synthesis of C3'-C5'-Linked Ribooligonucleotides. VIII. The Synthesis of Ribodinucleotides Bearing 3'-Phosphomonoester Groups
Polynucleotides. XLIX. Stimulation of the binding of aminoacyl-sRNA's [soluble RNA] to ribosomes byribotrinucleotides and a survey of codon assignments for 20 amino acids
Polynucleotides. XXXIX. Synthetic deoxyribooligonucleotides as templates for the DNA polymerase of Escherichiacoli: new DNA-like polymers containing repeating nucleotide sequences
1967
Studies on polynucleotides, lxviii the primary structure of yeast phenylalanine transfer RNA
1968
Studies on polynucleotides, XC. DNA polymerase-catalyzed repair of short DNA duplexes with single-stranded ends
Studies on polynucleotides. LXXXVII. The joining of short deoxyribopolynucleotides by DNA-joining enzymes
1974
Rapid separation of synthetic oligonucleotide mixtures on aromatic cellulose derivatives
1979
Total synthesis of a gene
Chemical synthesis and cloning of a tyrosine tRNA gene
1981
Synthesis of modified fatty acids and glycerophospholipid analogs
(Addendum:
An alternative method of preparing radiolabeled photoactivatable fatty acids
)
1984
Specific amino acid substitutions in bacterioopsin: Replacement of a restriction fragment in the structural gene bysynthetic DNA fragments containing altered codons
1986
Total Synthesis of a Gene for Bovine Rhodopsin
Methods for mutagenesis of the bacterioopsin gene
1995
Proton transport by a bacteriorhodopsin mutant, aspartic acid-85-->asparagine, initiated in the unprotonated Schiff base state
1997
Structure and function in rhodopsin: Packing of the helices in the transmembrane domain and folding to a tertiary structure in the intradiscal domain are coupled
1998
Research Programs in Japan
1999
Structure and function in rhodopsin: kinetic studies of retinal binding to purified opsin mutants in defined phospholipid-detergent mixtures serve as probes of the retinal binding pocket
Structure and function in rhodopsin: Further elucidation of the role of the intradiscal cysteines, Cys-110, -185, and -187, in rhodopsin folding and function
Structure and function in rhodopsin: effects of disulfide cross-links in the cytoplasmic face of rhodopsin on transducin activation and phosphorylation by rhodopsin kinase
Single-cysteine substitution mutants at amino acid positions 55-75, the sequence connecting the cytoplasmic ends of helices I and II in rhodopsin: reactivity of the sulfhydryl groups and their derivatives identifies a tertiary structure that changes upon light-activation
2001
Structure and function in rhodopsin: Mass spectrometric identification of the abnormal intradiscal disulfide bond in misfolded retinitis pigmentosa mutants
Probing the dark state tertiary structure in the cytoplasmic domain of rhodopsin: proximities between amino acids deduced from spontaneous disulfide bond formation between Cys316 and engineered cysteines in cytoplasmic loop 1
Solution 19F nuclear Overhauser effects in structural studies of the cytoplasmic domain of mammalian rhodopsin
2002
Solution NMR spectroscopy of [α-
15
N]lysine-labeled rhodopsin: The single peak observed in both conventional and TROSY-type HSQC spectra is ascribed to Lys-339 in the carboxyl-terminal peptide sequence
2003
Retinitis Pigmentosa Rhodopsin Mutations L125R and A164V Perturb Critical Interhelical Interactions
2005
Light-Driven Activation of β2-Adrenergic Receptor Signaling by a Chimeric Rhodopsin Containing the β2-Adrenergic Receptor Cytoplasmic Loops